Gastroprotective effect of Ferulopsis hystrix (Bunge) Pimenov in ethanol-induced gastropathy

The aim of the study was to evaluate gastroprotective effect dry extracts from roots and rhizomes Ferulopsis hystrix in ethanol-induced gastropathy. Materials methods . studies were carried out on 68 white Wistar rats. Ethanol-induced gastropathy simulated by a single intragastric administration ethanol dose 10 ml/kg. Animals experimental groups received medicinal forms F. : I – decoction volume ml/kg; II–V 200 mg/kg, obtained extraction with purified water, 30, 40 70% ethanol, respectively; VI extract, prepared double 40% 30% for 7 days before modeling Number structural changes determined gastric mucosa. They differentiated into small, large, strip-like erosions. Pauls’ index calculated changes. Pathomorphological stomach out. Results. total number animals I, II, IV V is 44% lower average, group III it 67% 3.6 times than control. large erosions I–V 38–75% lower, 83% control animals. No are detected III–VI. these destructions II 7.0 6.5 Microscopic morphological examination registered increase shallow-like groups. Shallow-like do not reach muscularis mucosae Microcirculation disorders leukocyte infiltration less pronounced group. Conclusion. has effect, increasing resistance mucosa ethanol. extract shows most pharmacotherapeutic